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How about we play, "Never have I ever"? (fedia.io)

submitted 1 month ago by bizarroland@fedia.io to c/asklemmy@lemmy.ml

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Here's the rules:

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[–] tetris11@lemmy.ml 2 points 1 month ago* (last edited 1 month ago) (2 children)

where does the tolerance come from though? With alcohol it's very clear that there's one organ doing the heavy lifting. With weed, I have no idea.

To each their own though, not trying to pressure anybody.

Of course! Likewise, I'm not trying to shame anyone for picking weed over beer. Each to their own

Edit: Apparently it's "CB1 receptor density" in your brain that handles the tolerance.

[–] deranger@sh.itjust.works 2 points 1 month ago

With alcohol it's very clear that there's one organ doing the heavy lifting

It’s not your liver, it’s your GABA receptors downregulating that gives you a tolerance. Your liver helps with the duration and hangover but the lower peak intoxication is mediated by the receptors. Likewise with cannabis, your THC receptors downregulate to give you a weed tolerance. It is also processed by the liver.

[–] WeirdGoesPro@lemmy.dbzer0.com 2 points 1 month ago

Indeed, a lot of drugs that are non toxic have tolerance created in the brain, while more toxic drugs have to get processed by the kidneys and liver, which is why the functioning of those organs contributes to tolerance.