https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824348/
A range of negative adverse effects have been associated with chemical castration. Like surgical castration, it initiates andropause (a male equivalent of menopause) and
may result in severe mood instability
and, in some cases, clinical depression. It may also cause weight gain, insomnia, hot flushes, diabetes, feminization, migraine headaches, and, especially in cases of long-term use, bone demineralization (Garcia and Thibaut 2011).
The violent outbursts also get worse, the health problem are a further point, but not the main one, i sadly cannot for the sake of it find the Study i read about it a while ago, but the findings where that the chemically castrated criminals that got released replaced the sexual urge with violence and had a way higher relapse rate, with worse crimes like murder.