Neurologist

joined 2 months ago
[–] Neurologist@mander.xyz 9 points 2 days ago

hmmm. To be honest, that’s an okay summary out of context, but it really fails to grasp the essence of the paper. It’s not wrong per say, but it adds irrelevant details while withholding key information. I wouldn’t rely on chatgpt’s summary for this.

[–] Neurologist@mander.xyz 11 points 2 days ago* (last edited 2 days ago) (1 children)

There’s a feature of some Long COVID cases (~50%) which is also the defining feature of an illness called ME/CFS which has been caused by various forms of viral infections throughout history. (It is thought that a lot of Long COVID cases are ME/CFS). Anyways this feature is, Post-Exertional Malaise, a worsening of the illness after exertion beyond a certain threshold, which can entail hundreds of symptoms and be permanent.

This paper is a review of some of the biomedical studies looking at what could possibly cause this, and finds there is repeated data of Microvascular (blood vessels) and immunometabolic (metabolic markers relating to immune function) differences with healthy controls.

The leading hypotheses are that this is caused by mitochondrial dysfunction which is mediated by a dysregulated immune system.

Some of my colleagues were co-authors on this paper. I’ll forward the feedback that it is jargony.

 

Background

A considerable number of patients who contracted SARS-CoV-2 are affected by persistent multi-systemic symptoms, referred to as Post-COVID Condition (PCC). Post-exertional malaise (PEM) has been recognized as one of the most frequent manifestations of PCC and is a diagnostic criterion of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Yet, its underlying pathomechanisms remain poorly elucidated.

Results

Upon physical activity, affected patients exhibit a reduced systemic oxygen extraction and oxidative phosphorylation capacity. Accumulating evidence suggests that these are mediated by dysfunctions in mitochondrial capacities and microcirculation that are maintained by latent immune activation, conjointly impairing peripheral bioenergetics. Aggravating deficits in tissue perfusion and oxygen utilization during activities cause exertional intolerance that are frequently accompanied by tachycardia, dyspnea, early cessation of activity and elicit downstream metabolic effects. The accumulation of molecules such as lactate, reactive oxygen species or prostaglandins might trigger local and systemic immune activation. Subsequent intensification of bioenergetic inflexibilities, muscular ionic disturbances and modulation of central nervous system functions can lead to an exacerbation of existing pathologies and symptoms

[–] Neurologist@mander.xyz 1 points 1 month ago (1 children)

Are octopus related to octopus? I mean technically they’re 100% related, but also they aren’t related as related implies not being. Depends on your interpretation.

2
🐊🐓🦖 (mander.xyz)
submitted 1 month ago* (last edited 1 month ago) by Neurologist@mander.xyz to c/science_memes@mander.xyz
 

If you’re confused: Birds are dinosaurs, crocodiles aren’t; note the “closest living relatives

 
[–] Neurologist@mander.xyz -4 points 1 month ago (2 children)

FYI, you seem to be new here and seem not to be far-left. For your future enjoyment of lemmy, note that Lemmy.ML is a communist instance and therefore you may not like some of the content there.

 
[–] Neurologist@mander.xyz 7 points 1 month ago

Lac Léman, is the french word for what english people call lake geneva (all the region around lac léman is french speaking).

Léman comes from celtic “lemann” which means lake.

So lac léman is the lake lake. Given it is the biggest lake in western europe, not a bad name.

 
 
[–] Neurologist@mander.xyz 1 points 1 month ago

That’s not how these collegues treat them.

They act like you can basically “think yourself out of” most mental illnesses.

[–] Neurologist@mander.xyz 5 points 1 month ago* (last edited 1 month ago)

unpopular opinion is not the same thing as academic literature lol makes sense.

Though I found the points to be well thought it (if not clearly written in a rush).

Also to be fair given the post, they could likely be a med student or something. Most people aren’t aware of the specific biological factors they listed nor some of the conditions, as OP used some medical terminology not often seen used by layman.

[–] Neurologist@mander.xyz 2 points 1 month ago

Yeah thats how it sounds to me 😂

Its patient blaming all the way in my (non-official) opinion

[–] Neurologist@mander.xyz 5 points 1 month ago (4 children)

That’s only in some schools of thought of psychology.

There are plenty of praticing psychologists and psychiatrists (some of my colleagues) who genuinely believe and publish research along the lines of “all mental illness are caused by thoughts and behaviours”. Research that in my opinion is heavily flawed, but still published and peer reviewed, so a lot of people in the field think this way.

[–] Neurologist@mander.xyz 13 points 1 month ago (2 children)

As a neurologist (specialising in post-viral illness) I don’t have the expertise to comment on points 2 and 3 of your post, but point one is completely correct.

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