this post was submitted on 03 Nov 2024
106 points (93.4% liked)

science

14786 readers
129 users here now

A community to post scientific articles, news, and civil discussion.

rule #1: be kind

<--- rules currently under construction, see current pinned post.

2024-11-11

founded 1 year ago
MODERATORS
top 7 comments
sorted by: hot top controversial new old
[–] Kayday@lemmy.world 76 points 1 week ago (1 children)

"The rule in question, known as Bredt's rule in textbooks, was reported in 1924. It states that molecules cannot have a carbon-carbon double bond at the ring junction of a bridged bicyclic molecule, also known as the "bridgehead" position. The double bond on these structures would have distorted, twisted geometrical shapes that deviate from the rigid geometry of alkenes taught in textbooks.
...A paper published by UCLA scientists in the journal Science has invalidated that idea. They show how to make several kinds of molecules that violate Bredt's rule, called anti-Bredt olefins, or ABOs, allowing chemists to find practical ways to make and use them in reactions."

[–] BreadOven@lemmy.world 4 points 1 week ago

Anti-Bredt double bonds have been a thing for a long time. Taxol (Paclitaxol) comes to mind.

Sorry if this is touched on in the article. I'm going to read it now.

[–] RQG@lemmy.world 43 points 1 week ago

As a chemist when I read such a title I already know it's one of those organic chemistry rule of thumb rules. All of them are named and most of them old and from text books. Such rules are useful rules for drawing stick figures of molecules. They are not the same as actual rules of physics for example.

But it's always cool when someone finds out how to make molecular structures we thought wouldn't work.

[–] MonkderVierte@lemmy.ml 2 points 1 week ago

Big deal. How much years is the half-life time of information in molecular science?