There are APIs that you can use to post and comment, etc... But there has to be an instance at that domain.
That's how most of the mobile apps work btw, they just send a network request direct to lemmy.world etc... Saying that iopq wants to create a post with this title and this content....
But there's no need for your own personal domain name in this scenario, you just need an account on the server that you're trying to post or comment to.
Not sure if that helps.