This is a most excellent place for technology news and articles.
The vaccine works by instructing the body to make up to 34 “neoantigens.” These are proteins found only on the cancer cells, and Moderna personalizes the vaccine for each recipient so that it carries instructions for the neoantigens on their cancer cells.
That’s pretty dope
You mispelled "expensive."
He must be one of those non-Americans with universal healthc*re
Ew, I can feel myself getting healthier just parsing the word "u******l a***r". You need to censor more of that.
I wonder if, even at this early stage of the therapy’s development, this would actually be more affordable than the alternative.
Melanoma patients are highly likely to have the cancer come back and or metastasize. Repeat treatments and hospitalizations are not cheap.
It'll be reasonably expensive, but sequencing and gene alteration is way cheaper than in needs to be.
If this can actually cure cancers, it may even be worth it.
The thing is, surely there's antibody against cancer antigens anyway, in ordinary cancer. A cancer cell expresses epitopes not on healthy cells.
Why is this better?
Also sounds very hard to do a proper controlled trial on. Every treatment produces a different protein, so there's no consistent factor to test except for the delivery mechanism.
Time for the antivax doomsday cult to extol the virtues of cancer.
god wants the children to have incurable tumors
No one ever said "God wants me to have incurable tumors." It's always someone else who should suffer. This is the opposite of the early Christian message. I would almost say, if you are not helping people to the point of discomfort, you are missing the point of Christianity.
“We think that in some countries the product could be launched under accelerated approval by 2025.”
Thats literally next year. That's amazing.
Can't wait to see what other uses we can find for mRNA
Cure for auto immune diseases is incoming FWIW
I wish. My kids are coeliac i.e., the presence of gluten in food causes the body to attack its own gut.
I'd love if there were a vaccine that they could take once, or even every several months that would let them eat what they wanted. It would have to be something that either turns off the errant immune response altogether or teaches the body to tolerate / ignore gluten proteins.
Does anyone know yet if long COVID is an auto-immune disease? I only assume it is but otherwise don't know.
Fuck cancer, this sounds great!
You know what this sounds like to me?
Like Moderna is gonna ask $10k a poke.
Edit: ITT: Pharma bros telling me how awesome artificially-inflated medication prices are.
In this case, you have to develop an individual vaccine for every patient based on the DNA from their own cancer. That’s actually a lot of work. $10K a poke is very reasonable given that you could easily spend 10 or 100 times that on conventional treatment.
Okay but forcing someone to pay you $550k (averaging your values) to not die maybe is still incredibly fucking awful, so it's really not hard to be better than that.
I can respect that developing a personalized vaccine might take a lot of work but I'm not a chemist. I don't know how much work it actually takes, nor do I know how many vaccines a person would realistically need to cure their cancer be it stage 1 up to stage 4?
What I do know is that if this vaccine ends up being more effective than the traditional method then it is a wonderful discovery, but if it leads to life-long medical debt and subsequent financial ruin all the same your life is still fucked.. I guess I'd rather be poor and alive, but I'd also rather not be destitute.
I know it sounds awful, but I've had family members die of cancer in the US and Europe, and 10k for a cure wouid have been a bargain in either case.
And hopefully with time the price will come down.
If this truly works, it'll be one of those things that cheaper for society to pay for than letting the disease drag on and fighting it with our old methods.
LOL I just remembered that some folks in the anti-covid-vax/maga category have been referring to the mRNA covid vaccines as 'the cancer vaccines' based on disinformation that they would 'interact with your genes' and 'give you cancer in 2 years'
Seeing this headline [Moderna’s mRNA cancer vaccine works even better than thought] I had to look to see if it was the cancer-targeting vaccine or some mouth-breathers talking about the covid ones 😅
I'm going to preface this by saying I had the moderna series and all boosters. Also had COVID once, ironically the weekend before Id scheduled a booster. I entirely believe that the vaccine is effective at reducing infection rates and severity.
have been referring to the mRNA covid vaccines as 'the cancer vaccines'
Ironic, because they literally started as "cancer vaccines", literally a niche cancer treatment. When they were first approved in 2008.
based on disinformation that they would 'interact with your genes' and 'give you cancer in 2 years'
We really don't know the long term consequences of mRNA vaccines. The COVID vaccine is the first application of them at large scale, and the first application of them where we'd normally expect most recipients to still be alive and mostly healthy ten years down the road (again, because they were originally created as a cancer treatment).
Check in in 2030 and we'll know whether or not we made a good bet on that one. We probably did, but there's a reason the manufacturers were given immunity from liability for anything that comes of the COVID vaccines.
There is a common misconception that long term effects will manifest long after the injection. All vaccines with longterm effects manifested their effect shortly after the injection. It makes little sense that you will have adverse reactions months or years later because the compounds are long gone from your system.
There was also the misconception that the vaccine was rushed and that steps were skipped or shortened during testing. That is not the case. The administrative processes were prioritized and there was a huge amount of test candidates so testing could be done much quicker. The normal process is not longer because they want to gather more long term data but because it just takes longer to gather it.
We really don't know the long term consequences of mRNA vaccines.
We know they are way safer than the old DNA vaccines because they don't literally give you a small dose of the virus like the old vaccines.
I wonder if my mom will accept this vaccine for her cancer after years of believing all the conspiracy theories about the COVID vaccine. I’m willing to bet that if she has the opportunity, she’ll jump on it.
I never once thought about it before but how do they select a target antigen for what is effectively a human cell? Maybe they could take a similar approach to Rabies or Prion Disease.
Can't wait for it to be specifically priced for only the 1% to be able to afford. Just like all the other cancer drugs that work.
It’s for rich folk. Not for us poors. Elysium.
what's really cool is this plus telomerase will give us a youth serum
what's really cool is this plus telomerase will give the extremely wealthy a youth serum
FTFY
Here's the thing: we're not getting many people to the natural limits of the human body's age much less working out ways to go past that.
Jeanne Louise Calment was 122 when she died. There's a hypothesis that she switched identities with her mother at some point, but most scientists who study aging don't consider it credible. Many other supercentenarian claims don't hold up; they often come from places that had bad record keeping a century ago, and they just forget how many birthdays they've had. 115 seems the typical limit for most people, but even that might have very few legit claims.
There are so few people who make it that far that they're basically rounding error even when including incorrect claims. Monaco has the highest average life expectancy at 87. We should be able to add almost 30 more years to that before we even talk about extraordinary youth serums.
Better cancer treatments will be part of getting us there, but far from the only factor.
telomeres are cells' biological clock... they get shorter with each division, and is the general cause of your body breaking down, round the 80's.
telomerase and other chemicals can reset those telomeres, but also cause the body's existing precancerous cells to go malignant. (telomeres also limit cancer cell growth, and creating telomerase is one of the mutations required for full on cancer)
so, if we can regrow cells telomeres without causing cancer... we have a youth serum.
but there's already other telomerase gene therapy in development anyways...
