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Youre assuming there's no use in using intoxicants, but there very much are. Arguably the most important, in terms of larger humanity.
Those "deeply grained" attitudes are the product of 20th century propaganda.
https://en.m.wikipedia.org/wiki/The_Great_Binge
In WWI it was completely normal to send your son/friend a package of morphine, cocaine and syringes.
And what I'm talking about is "mind-expanding" substances.
Alcohol literally depresses neural activity and makes it so you lose your coordination and eventually get sedated. It's the most "lazy" substance there is, yet none of these "deeply ingrained" attitudes concern it?
So no.
I don’t think there is a correct answer to the question you are posing. You asked for people’s opinions and I gave you mine.
Did you ever stop to think that the propaganda you speak of is directly influenced by exactly what steeznson was speaking about?
Why do you believe that anti-drug propaganda only began in the 20th century?
Do you have anything other than wikipedia links to back your stance up? Say, a real study done on the impacts of anti-drug propaganda through the ages which demonstrates that the 20th century was the most militant with it?
Do you know what Religion is, and its impacts on anti-drug mentalities predating the 20th century?