Nomad has host volumes - so you can tell it to mount a folder from the machine on the container, and it will only schedule that container on machines that have that folder. So yes, effectively you pin the workload, thus introducing a SPOF - I do not love it but Grafana only supports sqlite and postgres, so making those HA would require failover setups which is a bit much for a homelab :')
For backing up, you can use the sqlite command periodically (do cron job or Nomad periodic job) and then upload the backup to some external, safe storage (could be seaweedfs or S3!). For postgres you can use something like this.
Good luck on your Nix journey! Happy to help if you have questions.
Of all the tech I use, I think Nix is the most 'avant-garde' in that it is super different from the usual methods (scripting, stateful things), but works very well once past the paradigm shift and the learning curve that entails.