Ants make honey?
bunkyprewster
joined 1 year ago
They might be stupid.
Abstract
A hallmark of eukaryotic aging is a loss of epigenetic information, a process that can be reversed. We have previously shown that the ectopic induction of the Yamanaka factors OCT4, SOX2, and KLF4 (OSK) in mammals can restore youthful DNA methylation patterns, transcript profiles, and tissue function, without erasing cellular identity, a process that requires active DNA demethylation. To screen for molecules that reverse cellular aging and rejuvenate human cells without altering the genome, we developed high-throughput cell-based assays that distinguish young from old and senescent cells, including transcription-based aging clocks and a real-time nucleocytoplasmic compartmentalization (NCC) assay. We identify six chemical cocktails, which, in less than a week and without compromising cellular identity, restore a youthful genome-wide transcript profile and reverse transcriptomic age. Thus, rejuvenation by age reversal can be achieved, not only by genetic, but also chemical means.
How does the bank make money from your money?
If I leave a pile of money in my closet, it doesn't grow like mold.
Do we have ol' lemmy stuff now?
Having money means you automatically get to have more money - ie interest, rent, investments.
So, who would win?
By the same people who fought against student loan forgiveness.
Strictly Ballroom
Can one still download Swype?
Oh, like Mr. Darcy!