A game moment to do again with no memory? Leaving the sewers for the first time in Oblivion. It was the first open world game I had ever played as a kid, and seeing the glare of the sun and realizing that everything I saw was able to be explored? Pure gaming magic.
A whole game to do again? Disco Elysium. There are plenty of ways to go back through the game on another playthrough and do things differently, but there is nothing quite like the first run of that game.
Same thing happens all the time in places with "edgy" or just plain offensive humor. Some people see it and think they are just being funny, others see it and think they found a group where hateful views are accepted. 4chan started the same way before it became a cesspit. Turns out when everyone is repeating racist and sexist jokes, that some of them aren't joking.