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Some substances help with tasks such as operating machinery for extended periods e.g. stimulants in the amphetamine class of drugs, methamphetamine, dexamphetamine, etc. Cocaine is probably also helpful.
The U.S. Air Force uses dextroamphetamine as one of its "go pills", given to pilots on long missions to help them remain focused and alert.
It doesnt help with operating machinery, it helps with not falling asleep while doing it. Sleep deprived/exhausted people shouldnt be operating heavy machinery and definitely, shouldnt be taking highly addictive drugs to enable them to do it either. Its sad that their work conditions sometimes forces them to do so.
