My first thought comes to one of the first missions of the game with Maelstrom, between Royce and Brick.
I usually save Brick in that mission and I could picture him playing a role like Wrex from Mass Effect. One of the biggest leaders of Malestrom, their gang now bigger and nastier than ever, no one wants to fuck with them. Brick is in charge, and when V shows up, ready to draw guns again, Brick appears and he gives you that big tough guy respect like how Wrex did, saying this is the crazy motherfucker who saved my life and proceeded to blow up half of Night City afterwards.
There's so many small things I could picture being different in the sequel. I hope this will be the case since even The Witcher 3 had some pretty significant changes to the story depending on the options you chose about what happened in The Witcher 2.