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Microdosing Psilocybin - Repeated low doses of psilocybin increase resilience to stress, lower compulsive actions, and strengthen cortical connections to the paraventricular thalamic nucleus in rats (osf.io)

submitted 1 year ago by treefrog@lemm.ee to c/science@lemmy.ml

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Dose was 0.05mg/kg administered every other day.

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[–] eighthourlunch@kbin.social 2 points 1 year ago (3 children)

In rats. I've yet to read a human study on microdosing that showed any effects greater than placebo.

[–] treefrog@lemm.ee 8 points 1 year ago (1 children)

They demonstrated positive physiological charges. We don't cut people up. I have mixed feelings about animal testing but without a longitudinal study on humans it is hard to demonstrate positive outcomes. Become of placebo as you mentioned.

In other words, we don't do this kind of study on humans because the subjects get cut up at the end.

My hope is this will encourage more testing in humans. The data from this study is promising, even if it's just rats...

[–] eighthourlunch@kbin.social 4 points 1 year ago (1 children)

There have been plenty of studies on psilocybin with human subjects. None of them included vivisection or bisection. We have other ways of testing this sort of thing.

[–] treefrog@lemm.ee 4 points 1 year ago (1 children)

Right.

But the placebo affect makes positive outcomes harder to measure with microdosing, as you said.

I think we do need more studies on humans, and while I don't like that they killed animals I keep as pets, I do hope this will encourage more human studies.

[–] django@discuss.tchncs.de 3 points 1 year ago

Also the placebo effect is harder to tackle in this instance as people are often able to tell if they actually got psilocybin administered or not.

[–] SpezCanLigmaBalls@lemmy.world 1 points 1 year ago

It completely took away any anxiety I had. I had incredibly bad anxiety, to the point in college I wouldn't leave my room if I heard voices in the house. Within months of microdosing my anxiety diminished significantly. Then all of a sudden I realized I didn't have social anxiety anymore and my mind was very calm.

I did it about every other day for 4 months and then without realizing it it turned into 2 times a week then once a week and then every other week. I just did .15 grams. Due to the decrease of anxiety it helped my depression. I was able to think things through clearly. It truly did help me

[–] Bremmy@lemmy.ml -4 points 1 year ago (1 children)

Very misleading title

[–] scottywh@lemmy.world 6 points 1 year ago (1 children)

It hasn't been edited and specifically mentioned that this was in rats.

I don't see how the hell that could be considered misleading.

[–] treefrog@lemm.ee 2 points 1 year ago

I didn't either and thank you for saying so.