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I personally know a person with a child who was born with profound physical and mental disabilities. She's a dear sweet caring person, and she shared an emotionally devastating story about how she had her first "conversation" with her daughter when said daughter was in her early twenties, which took the form of the daughter being able to indicate, through extraordinary effort, that she preferred to be read one story instead of another.
For her, this was a deeply rewarding moment, the ability to have any kind of deliberate interaction with her daughter, after nearly two decades of struggle and effort. She clearly loves her daughter. I would never try to take anything away from her in that regard.
However. When my wife got pregnant we had very serious conversations about the potential for birth defects and how we were prepared for her to have an abortion if serious defects were found. We talked about the quality of life of a human being we were bringing into existence, and how no one should ever have to feel trapped by their own body, and what our experience of being parents was going to be like.
Our daughter was born without any issues at all. In fact she's bright and friendly and less destructive than we might have expected... and still being a parent is easily the most intense and difficult project of my entire life, mentally, physically, and emotionally. Nobody should ever have any reservations about being a parent for any reason at all, and if there are factors that you can control to make that decision easier one way or the other, then you should absolutely take control of them.
All of which is to say, no there is absolutely no moral issue with choosing not to deliberately create a person with genetic birth defects. The choice to become a parent is the most important and consequential choice anyone can make. Make it in exactly the way that you would want to make it, and in no other way whatsoever.