this post was submitted on 20 Mar 2024
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The problem is if you leave a single provirus, HIV can return. It's different than needing to supply a functional form of a protein to enough cells that the body benefits. You can get high delivery rates with enough effort. But 100%?
By prolonging the anti retroviral therapy (with a regime containing a Reverse Transcriptase or Ingetrase Inhibitor) for a certain time after the CRISPR-Cas treatment should lead to the complete elimination of the viral DNA, comparable to PrEP in un-infected individuals.