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I think the problem is that not everyone translates text in their brain the same way.

I translate it as if I were speaking it. So when I see "We invited the strippers, JFK and Stalin," I read it exactly as I'd say it, which is, the strippers were JFK and Stalin. When I read "We invited the strippers, JFK, and Stalin", the comma pause is not rendered as text in my brain, but like a quarter-rest in a musical score, and that pause is what allows my brain to separate JFK and Stalin from each other.

Other people translate text more visually, I guess, and that problem doesn't exist there? I wouldn't know, I can't even begin to fathom how "JFK and Stalin" could be read in any way that doesn't mean they're the strippers.

I mean, if you were trying on purpose to say JFK and Stalin were the names of the strippers, and not the dead historical figures, how would you punctuate that sentence? Without the Oxford comma, the clause is clearly an appositive, not a list.

And then when you get into longer lists, it becomes even more of a pain in the ass. "Some suggested treatments for this condition are patella surgery, physical therapy and exercise, plate insertion, bone fusing and bedrest, among others." Is "bone fusing and bedrest" one item? We have another item in the list that's a combination treatment with "and", is this also one? Or are they two separate treatments? Did the author omit the Oxford comma, or did they omit the Oxford "and"? It's very common for academic authors, particularly, to make that kind of typo. They drop articles and conjunctions all the time. Now I have to e-mail the author and ask "What did you mean here?" because, as the editor, I can't just assume "oh, they don't like the Oxford comma, so this sentence is fine". There are a lot of places where a small typo like missing "and" will make or break the intended meaning and the scientific veracity of an academic paper.

So yeah, I guess if all your writing is stylistic fiction where precision isn't important, and your reading style is visual rather than auditory, an Oxford comma might "look ugly" and it could be safely ignored. But for anything technical, it's kind of important.