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An immunologist explains why the immune system works best when balanced, not 'boosted'
(www.livescience.com)
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Except for the Vitamines E, D, K and A, Vitamines are takes up in a controlled way so you cant really overdose them. Overdosing VitA can cause blindness So thats no joke either.
Im no expert on supplements but I know that the new chemotherapies for cancer that include an upregulation od the immune system have autoimmune diseases as a side effect. But I guess you would have to apply that harsh measures to unleash autoimmune diseases.