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The Shapeshifters from Deep Space 9. They put a pox on an entire race for being disobedient.
Which aliens got the po?
I dont remember the name of the episode, but Bashir took a leave of absence and hung out on this planet for, I'd guess, a year to work on a cure. He didn't find a cure but managed (by accident) to make a vaccine that saved new-borns from getting infected.