The instance seems to be mostly right wing trolls. I know defederating is unpopular but I don't think much is to be lost in this case and it can save the mods some headaches.
Edit: the response on exploding-heads.com to my reporting of transphobia. Courtesy of the "second in command"
The existence of people who detransition is often brought up in anti-trans circles as a criticism of gender-affirming care. However, the actual number of trans people who even just regret getting medical treatments is like 0.5%. Versus something like 14% for medical surgeries in general. And this is including trans people who regret it for social or economic reasons.