The instance seems to be mostly right wing trolls. I know defederating is unpopular but I don't think much is to be lost in this case and it can save the mods some headaches.
Edit: the response on exploding-heads.com to my reporting of transphobia. Courtesy of the "second in command"
That functionality doesn't exist yet as far as I know so the best bet is to ask the instance you're on "Would we defederate over this" and if the answer is no, change instances