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Immune Checkpoint Inhibitors Market Forecast to 2020 The Global Immune Checkpoint Inhibitors Market Report is a comprehensive report on the Immune Checkpoint Inhibitors market, offering key insights on business strategies, current trends, and presenting qualitative and quantitative analysis of the Immune Checkpoint Inhibitors market. This report offers in-depth research insights on key and significant aspects of the Immune Checkpoint Inhibitors market, providing an in-depth analysis of key drivers, restraints, restraints, growth prospects, threats, and risks. The report also includes an in-depth analysis of the competitive landscape and regional scope of the Immune Checkpoint Inhibitors market. Additionally, the report will be updated in line with changes in market dynamics and economic scenarios due to the COVID-19 pandemic. This report assesses the impact of the pandemic on the overall market and provides an in-depth assessment of the current and future impact of the COVID-19 pandemic on the industry. The global Immune Checkpoint Inhibitors market report employs an extremely extensive and perceptive process that analyzes statistical data relating to services and products offered in the market. The research study is a pivotal document in understanding the needs and wants of the clients. The report is comprised of significant data about the leading companies and their marketing strategies. The Immune Checkpoint Inhibitors industry is witnessing an expansion and change of dynamics owing to the entry of several new players. To know more about the report, visit @ https://www.rootsanalysis.com/reports/immune-checkpoint-inhibitors/303.html

Global 3D Printing Materials Market Forecast to 2035 The global 3D Printing Materials Market study report provides an exclusive analysis of the current market size and future growth opportunities. This comprehensive study on the global 3D Printing Materials market provides brief guidance to the market vendors, stakeholders, participants, and emerging players on dealing with the post-pandemic market downfall. In this latest report, our researchers have provided valuable insight into market dynamics to business strategists, investors, industrial leaders, and stakeholders during the forecast period 2024-2035. The market report highlights the current market value, emerging trends, and projected growth rate for the upcoming years. In addition to market trends, the market study report also features an analysis of the COVID-19 impact on major segments covered in the market. Our study report also provides insightful information on current and future growth predictions, along with the impact of a pandemic on the overall growth of the industry. Market Segmentation Overview: The market report distributes the global 3D Printing Materials market on the basis of product types, end-users, applications, and key geographical regions where the market has established a remarkable presence. In this report, our authors discuss the supply-demand ratio, production and consumption volume across various segments of the 3D Printing Materials market. Market Share Based on the Key Geographical Region In the market study report, the global 3D Printing Materials market covers an in-depth analysis on major regions including North America, Europe, Asia-Pacific and rest of the World. The key discussion on region-wise distribution provides an overview about regional players, regional dominances, new entrants and strategic collaborations, merger, acquisitions and partnerships to develop innovative products. The various regions analyzed in the report include: ● North America (U.S., Canada) ● Europe (U.K., Italy, Germany, France, Rest of EU) ● Asia Pacific (India, Japan, China, South Korea, Australia, Rest of APAC) ● Latin America (Chile, Brazil, Argentina, Rest of Latin America) ● Middle East & Africa (Saudi Arabia, U.A.E., South Africa, Rest of MEA) Market Competitive Landscape The section on the market competitive landscape provides actionable insight into the business sphere of 3D Printing Materials market and key companies engaged in the market. This detailed market analysis report provides deep information about market size, revenue share, pricing analysis, product portfolio, and strategic alliance, including acquisitions, mergers, collaborations, joint ventures, partnerships, product launches, and brand promotions. In this report, our researchers cover an in-depth discussion over strategic initiatives taken by the industrial leaders to mitigate the ongoing challenges and post pandemic impact on the market. SWOTs and Five Porter’s Analysis on Global 3D Printing Materials Market Our report covers a qualitative and quantitative analysis on current scenarios, emerging trends, regulatory framework across various regions, production and consumption patterns, supply and demand dynamics, and the presence of leading players in the area. In order to offer competitive edge, our researchers briefly discuss the SWOT analysis and Porter’s Five Forces Analysis. The detailed information helps to understand the strength areas of the market, weaknesses, opportunities and threats that can impact the market growth during the forecast period. The in-depth study helps stakeholders in understanding the level of competition in the market, threats due to new entrants as well as established players, product / services competition and supply chain disruption. Research Report on the 3D Printing Materials Market Addresses the Following Key Questions: ● What are the key market drivers of the 3D Printing Materials market? ● Who are the leading players in the 3D Printing Materials market? ● Which regional segment of the market is anticipated to show the highest growth potential during the forecast period? ● What are the current consumer trends and future demands that are expected to influence the business operations of the leading players engaged in the 3D Printing Materials market? ● What are the major restraining factors that impede the growth of the 3D Printing Materials market during the forecast period? ● What are the expansion plans and strategic investment plans undertaken by the players to gain a robust footing in the market? ● What is the overall impact of the COVID-19 pandemic on the 3D Printing Materials market and its key segments? To know more about the report, visit @ https://www.rootsanalysis.com/3d-printing-materials-market Key Companies Profiled in the Report are Höganäs • IC3D • Lithoz • Markforged • Materialise NV • Proto Labs • Sandvik • Sculpeto • Solvay • Stratasys • Royal DSM • Tenthon 3D 3D Printing Materials Market: Industry Trends and Global Forecasts, Till 2035: Distribution by Type of Material (Ceramics, Metals, Plastics and Others), Form (Filaments, Liquid and Powder), Technology (Direct Metal Laser Sintering (DMLS), Fused Deposition Modeling (FDM), Selective Laser Sintering (SLS), Stereolithography (SLA) and Others), Application (Prototyping, Manufacturing and Others), Others Thank you for reading our report. To know more about the customization feature, please get in touch with us, and our team will ensure the report is customized to meet your requirements.
About Roots Analysis Roots Analysis is a global leader in the pharma / biotech market research. Having worked with over 750 clients worldwide, including Fortune 500 companies, start-ups, academia, venture catalysts, and strategic investors for more than a decade, we offer a highly analytical / data-driven perspective to a network of over 450,000 senior industry stakeholders looking for credible market insights. All reports we provide are structured in a way that enables the reader to develop a thorough perspective on the given subject. Apart from writing reports on identified areas, we provide bespoke research / consulting services dedicated to serving our clients in the best possible way. Contact Details Roots Analysis Gaurav Chaudhary +1 (415) 800 3415 +44 (122) 391 1091 Gaurav.chaudhary@rootsanalysis.com Website: https://www.rootsanalysis.com/

A woman has a lot to think about when she is pregnant. Women who are pregnant should take care of their teeth, for themselves and their kids. Most regular dental care is safe to do while pregnant, but you should avoid certain medicines and procedures for the first three months. Let your dentist know if you are expecting.

Take care of your teeth when you have morning sickness. Some pregnant women have morning sickness, which can include vomiting or acid reflux. Tooth erosion is more likely to happen when you vomit or have acid reflux, but there are a few things you can do to lower the risk. When you get over morning sickness, make sure you brush your teeth well. If you’re not at home and don’t have your toothbrush with you, rinse your mouth out with water right away or chew sugar-free gum. You can brush your teeth when you get home. Make sure your teeth and gums are healthy. Gum disease can hurt both you and your baby’s health. Poor tooth health in mothers has been linked to kids being born early and having low birth weight. Having healthy gums can also stop bacteria from getting to your baby. Keep an eye out for changes in your mouth health. Hormonal changes during pregnancy can make your body change in many ways. Bad breath, swollen, red, or bleeding gums are all signs of gum disease that you should watch out for. If any of these things happen to you while you’re pregnant, you should see a doctor. Give up smoking! People who use tobacco items are not healthy! If you smoke while you’re pregnant, it’s bad for both you and your baby. Too much tobacco use can cause many illnesses, including gum disease. You and your partner will both be better off if you quit! Take care of your teeth while you’re pregnant. Getting your teeth and gums cleaned by a dentist is important during pregnancy to keep them healthy. Make an appointment with your doctor during your second trimester. Tell them you are pregnant and about any medicines or pregnancy vitamins you are taking.

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Is it safe to wash your anus with water and your (ungloved) hand after pooping, assuming (of course) that you don't touch anything with your hand until you wash it with soap and water?

I'm currently traveling in India. It's common here, instead of using toilet paper after deification, to pour water down your back and use your left hand to wipe your anus clean of feces. I googled to find information from medical professionals to understand if this is safe or not, but I (surprisingly) couldn't find any information on the Internet about this.

Of course, let's assume that we're doing this properly:

1. You only use one hand (typically your left hand), so feces only contaminates one hand.
2. You don't touch anything in the bathroom (eg pitcher, faucet, door knob, etc) with your soiled left hand until after you wash your hands
3. You wash your hands properly, following best-practices: using soap and water, scrubbing vigorously for at least 20 seconds.

I'm less interested in your personal opinion, and more interested if any studies have been done analyzing the efficacy of safety in this scenario, using a proper scientific study.

Have any studies been done to analyze if it's safe to wipe your ass with your hand (and wash your hands properly with soap and water after)?

What are the differences between the different types of Alkaline Phosphatase (ALP) tests for laboratory blood work?

I went to a medical laboratory to get yearly blood work done. In addition to testing for some specific "me" things that I'm monitoring, I want to get a CMP (Comprehensive Metabolic Panel).

I'm in a foreign country where I don't really speak the language. When I said that I wanted blood work done at the lab, the agent at the front desk handed me a form with a lot of boxes to choose what I wanted to get. There is no "CMP" option, so I tried to tick the boxes for the 14 blood tests that compose a CMP, but I got stuck when I tried to check the box for the ALP (Alkaline Phosphatase) test – because there were 3 boxes:

1. Fost. Alcalina
2. Fost. Ácida Total
3. Fost. Ac. Prostatica

What are each of these, and which of these three is the "normal" ALP test that should be included in a CMP?

I've been diagnosed with a supraspinatus tendon rupture of about 1.1 x 1.2 mm on the supraspinatus tendon (posterior fibers). Roughly, how big is it in relationship with its global size? Half? 2 thirds? I'm a small guy - 1.6m tall.

Also, does the tendon recover?

I notice my arm is still a little bit anterior rotated and down a bit as well. About a year has passed.

Should I be worried with some kind of arthrosis down the line, because of the position of the humerus on the glenoid cavity?

A new study finds that getting your blood pressure taken while you’re lying down may give a more accurate reading that could show signs of heart disease risks. Even though the new study found something different, researchers agree that sitting up is still the best way to take blood pressure. Experts say that people should make it a priority to know their blood pressure numbers and act on them, because high blood pressure can make someone more likely to have dangerous heart events. New study shows that getting your blood pressure checked while you’re lying down may give more exact results.

Every time you go to the doctor, your blood pressure is taken for a reason. Blood pressure is often a good indicator of serious health problems, like the chance of stroke, heart disease, and even dying too soon.

So, it’s important to get the most exact reading of your blood pressure so you can take care of your health.

The American Heart Association (AHA) gave a talk earlier this month about how a person’s physical position when their blood pressure is taken can affect their blood pressure number, which in turn can affect how well they can predict certain health risks.

All of it comes down to where an adult is when they get a high blood pressure number.

Adults who had high blood pressure both when they were sitting up and when they were lying flat on their backs were more likely to have a stroke, heart failure, die too soon, or have heart disease than those who didn’t have high blood pressure in either pose.

CRAB is the name of a type of bacteria that can cause dangerous infections in the blood, lungs, and urinary tract, according to the U.S. Centres for Disease Control and Prevention. A group of strong medicines called carbapenems can’t kill it, which is a bad thing.

Researchers from Harvard University and the drug company Hoffmann-La Roche found that zosurabalpin, a new type of antibiotic, can kill A. baumannii in a study that came out on January 3 in the journal Nature.

Dr. Kenneth Bradley, global head of infectious disease discovery at Roche Pharma Research and Early Development and researcher, told CNN that Zosurabalpin works in a way that isn’t like anything else on the market.

His explanation was that this was a new way to do things, both in terms of the compound itself and the way it kills germs. It is hard to fight A. baumannii because it is a Gram-negative bacteria, which means it has protective membranes on both the inside and the outside.

Scientists first tried to find a molecule that could get through those double membranes and kill the germs. Then, they worked on making it even better.

Researchers picked one changed molecule after working for years to make many compounds stronger and safer.

How does it do its job? Zosurabalpin stops lipopolysaccharides, which are big molecules, from moving to the outer membrane of bacteria. There, they keep the protected membrane intact. This makes the molecules build up inside the bacteria cell until the cell becomes so poisonous that it dies.

More than 100 CRAB samples were used in the study, and zosurabalpin worked on all of them. It also lowered the amount of bacteria in mice that had asthma caused by CRABs and kept mice from dying of sepsis caused by the bacteria.

Researchers told CNN that Zosurabalpin is now being tried in phase 1 clinical trials to see if it is safe for people to use.

cross-posted from: https://midwest.social/post/6252553

Dec 7 (Reuters) - The Biden Administration on Thursday announced it is setting new policy that will allow it to seize patents for medicines developed with government funding if it believes their prices are too high.

The policy creates a roadmap for the government's so-called march-in rights, which have never been used before. They would allow the government to grant additional licenses to third parties for products developed using federal funds if the original patent holder does not make them available to the public on reasonable terms.

White House advisers said on a press call that cost to consumers is a factor government agencies may consider when thinking of using march-in rights.

"We'll make it clear that when drug companies won't sell taxpayer funded drugs at reasonable prices, we will be prepared to allow other companies to provide those drugs for less," White House adviser Lael Brainard said on the call.

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“We’ve found that antioxidants activate a mechanism that causes cancer tumors to form new blood vessels, which is surprising since it was previously thought that antioxidants have a protective effect,” said Martin Bergö, a new study’s author. “The new blood vessels nourish the tumors and can help them grow and spread.” It's worth noting that there's no harm in consuming normal antioxidant-rich foods in normal quantities, though.

Is There Meat Glue in Your Food? https://www.theepochtimes.com/health/is-there-meat-glue-in-your-food-5466911

Over the past several years, increasingly destructive hurricanes, wildfires, blizzards, and other extreme weather events have made it clear that the effects of climate change aren’t some future hypothetical, but our current reality. Not to be outdone, the summer of 2023 has been coming in hot — literally — with July shattering the record for the planet’s hottest month, and coming to a close with “numerous fires” breaking out in the Arctic circle. And while the recent high temperatures and debilitating humidity may not be responsible for as much property damage as a hurricane, it’s been disastrous for our mental health.

Diabetes cases are likely to skyrocket over the next few decades, new research out this week has found. The study estimates that more than a billion people worldwide will be living with the chronic condition by 2050—roughly double the amount of cases seen today. The prevalence of diabetes is expected to be especially high in parts of Africa and the Middle East, but dozens of countries could experience substantial increases.

Mental Health Apps Are a Privacy Nightmare

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In the simplest terms, diabetes is defined as having chronically high levels of blood sugar. This usually happens due to a breakdown in our production of or response to insulin, a hormone that helps move sugar from the bloodstream to our cells. People with type 1 diabetes, for instance, have an overzealous immune system that attacks the cells responsible for making insulin. And those with type 2 diabetes develop a resistance to insulin’s effects and can eventually stop producing it altogether.

Thanks to medications and better blood sugar monitoring, diabetes is no longer the death sentence it once was. But it can still lead to serious complications like nerve damage and chronic kidney disease, especially if not managed probably. It also often raises the odds of many other health conditions, including heart attacks, stroke, and dementia. And according to the authors of a study published Thursday in the Lancet, the burden of diabetes will only go up from here.

The research comes from scientists at the Institute for Health Metrics and Evaluation (IHME), based at the University of Washington’s School of Medicine. To come up with their predictions, the team used the latest data from the Global Burden of Diseases study, a long-running research project also managed by the IHME that tries to track the prevalence of and harm caused by many health conditions and illnesses.

Based on the GBD data, there were about 529 million people living with diabetes worldwide in 2021. After adjusting for age, the current global prevalence was around 6.1%. But by 2050, 1.31 billion people will have some form of diabetes, the authors found. The highest age-standardized prevalence rate for a large region is projected to be in North Africa and the Middle East, at 16.8%, but nearly half of the world’s over 200 countries and territories will have rates higher than 10%.

“The rapid rate at which diabetes is growing is not only alarming but also challenging for every health system in the world, especially given how the disease also increases the risk for ischemic heart disease and stroke,” said lead author Liane Ong, a lead research scientist at the IHME, in a statement released by the organization.

Over 95% of these cases are expected to be type 2 diabetes. And the single most significant risk factor associated with type 2 was high body mass index. But the authors note that many other important factors, including low levels of exercise, poor diet, and a person’s genetics, can influence the risk of developing diabetes and the potential harm or death it can cause. So preventing or managing diabetes cases now and in the future will require widespread improvements in our environment and availability of health care, the authors say.

“Some people might be quick to focus on one or a few risk factors, but that approach doesn’t take into account the conditions in which people are born and live that create disparities worldwide,” said study author Lauryn Stafford, a research fellow at IHME. “Those inequities ultimately impact people’s access to screening and treatment and the availability of health services. That’s precisely why we need a more complete picture of how diabetes has been impacting populations at a granular level.”

Has anyone heard similar?

What a surprise. /j

Well, guess I'm screwed since I bump my head, semicommonly…

Also, this is NPR, so it's unsurprising they whitewashed the U.S military.

Through its savvy but legal exploitation of the U.S. patent system, Humira’s manufacturer, AbbVie, blocked competitors from entering the market. For the next six years, the drug’s price kept rising. Today, Humira is the most lucrative franchise in pharmaceutical history. AbbVie orchestrated the delay by building a formidable wall of intellectual property protection and suing would-be competitors before settling with them to delay their product launches until this year. Over the past 20 years, AbbVie and its former parent company increased Humira’s price about 30 times, most recently by 8 percent this month. Since the end of 2016, the drug’s list price has gone up 60 percent to over $80,000 a year, according to SSR Health, a research firm. AbbVie did not invent these patent-prolonging strategies; companies like Bristol Myers Squibb and AstraZeneca have deployed similar tactics to maximize profits on drugs for the treatment of cancer, anxiety and heartburn. But AbbVie’s success with Humira stands out even in an industry adept at manipulating the U.S. intellectual-property regime.

“Humira is the poster child for many of the biggest concerns with the pharmaceutical industry,” said Rachel Sachs, a drug pricing expert at Washington University in St. Louis. “AbbVie and Humira showed other companies what it was possible to do.”