this post was submitted on 29 Jun 2023
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Aspartame is also linked in some studies to weight gain, GI disorders, mental health issues and more:

According to some studies, aspartame and other artificial sweeteners can lead to weight gain instead of weight loss 12. Aspartame has been linked to increased appetite, diabetes, metabolic derangement and obesity-related diseases 2.

One study showed that aspartame causes greater weight gain than a diet with the same calorie intake but no aspartame 1. Another study found that even acceptable daily intakes of aspartame might make you hungrier and lead to weight gain 3.

...some research suggests an association between aspartame intake and metabolic damage to the central nervous system (CNS), such as changes in enzyme and neurotransmitter activities 2. Aspartame acts as a chemical stressor by elevating plasma cortisol levels and causing the production of excess free radicals. High cortisol levels and excess free radicals may increase the brain’s vulnerability to oxidative stress which may have adverse effects on neurobehavioral health 3.

There is also some evidence that high-aspartame consumption may lead to weaker spatial orientation, irritability, depression, and other neurobehavioral conditions 14. However, these studies are limited in scope and further research is needed to determine the long-term effects of aspartame on human health.

Worth researching more, especially if you eat/drink anything with this stuff - and it's in a lot of food products.

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[–] varzaman@lemmy.one 20 points 1 year ago (1 children)

It's not this straight forward. I read the reuters article about this that goes into more detail.

https://www.reuters.com/business/healthcare-pharmaceuticals/whos-cancer-research-agency-say-aspartame-sweetener-possible-carcinogen-sources-2023-06-29/

But basically, IARC is only looking at if the substance can be carcinogenic, regardless of the quantity it takes for it to be harmful to humans.

There is another organization, called JECFA that is specifically for advice for individuals. This is where "food regulations" would come from.

The JECFA is set to show off their findings at the same time as IARC is gonna make their announcement. I feel like some of you guys are jumping the gun here due to the title of the articles coming out.

[–] BrainisfineIthink@lemmy.one 5 points 1 year ago

Click bait works, unfortunately.

[–] Chetzemoka@kbin.social 19 points 1 year ago (2 children)

Obesity is one of the leading preventable causes of cancer. Along with tobacco, alcohol, sun exposure, and red meat consumption. Aspartame is not a major cause of cancer in humans. If it helps you lose weight, then you're improving your cancer risk.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2515569/

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[–] Pietrasagh@lemmy.world 13 points 1 year ago* (last edited 1 year ago) (1 children)

Barbecue sausages are also carcinogenic. What matters is how much and in what doses. Hey WHO: Show me scientific, peer revieved, reproduced in independed labs papers with solid proofs. Not preliminary results of "one research". Then I will weigh pros and cons and decide if I should use it. Strangely decades of use under supervision of FDA and other reputable institutions had no remarks like WHO. Don't forget that dihydrate monoxide also promote cancer, and we all drink it like water.

/edit typo, grammar/

[–] gila@lemmy.world 13 points 1 year ago

Obesity is like the second biggest risk factor for cancers. This post reads like a non-medical professional's interpretation of medical advice. I don't mean to offend, because that is very common. But the information presented here is devoid of context in a way that makes it potentially misleading.

[–] HjFUN@lemmy.world 12 points 1 year ago (3 children)

Gonna try to cut a line down the middle and say I’m not seeing very convincing evidence one way versus another. Lotta finger pointing and honestly getting way more intense about diet soda than I thought anyone would.

Gotta say that my family (and me until high school) drink wayyy to much diet soda. Like sugar, or aspartame it’s a bit worrying and when you drink caffeinated sweetness all day you’re probably going to feel defensive about someone saying it’s gonna kill you.

I am a bit of the mind that it may only be significantly carcinogenic at super high doses, but who knows if anyone is getting those doses either from commercial beverages or mixing it in the same proportions as sugar in their iced tea

[–] ColonelSanders@kbin.social 2 points 1 year ago (1 children)

Was going to say, I'm all for changing my habits/thought processes based on scientific data/evidence, but I could've sworn this debate has been raging on for some time now. First it was declared that it causes Cancer, then it was declared well no there's not really enough evidence to support that, and now we're back to it does. But I have yet to see a definitive link in any study and even this article says "possibly."

Now, that being said I still avoid aspartame when possible, opting for Stevia whenever I have the choice. I just fear that this kind of back and forth tends to erode credibility through unsubstantiated whiplash with the general public.

[–] Zaktor@lemmy.world 3 points 1 year ago

As someone who would also very much like to believe that aspartame is perfectly safe, I will point out that in a controversy over "is this commercially sold product dangerous", the side that says "no" is going to get a lot more funding than the one that says "yes". Maybe there's some potential financial incentive for alternative sweeteners to boost aspartame-bad studies, but the aspartame-good group is very directly backed by behemoths.

These things aren't easy to prove and more research (from publicly funded sources) would be good, but when you're seeing a lot of confusing competing claims, keep in mind that industry funded research exists and it will be overwhelmingly on the side of "let us keep selling these very profitable products".

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[–] required@lemmy.world 12 points 1 year ago (1 children)

Honestly nothing can be more dangerous than the OG coke. The amount of sugar in that can is incomprehensible

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[–] nymwit@kbin.social 10 points 1 year ago (1 children)

I sort of cringe (more of a nose wrinkle really) at OP's "it's known in some circles to be bad" You see beliefs and correlative evidence constantly misrepresented as proof and truth in food and medical science (reporting and discussion).

I get it. The body is a hugely complicated system, it's hard to figure these things out. What does even figuring them out mean with the amount of complicating factors of this affects that which affects this which causes this.

I'm open to the idea that lobbying and such means Aspartame (and other industrial food products) has really been pushed through.

It's also obviously been studied quite a bit and it's hard to believe all the studies saying it's safe at recommended levels are bunk or fraudulent.

This news was on another instance where the discussion included that the IARC carcinogen classifications do not take into account exposure/dosage. A whole bunch of things can be carcinogenic depending on exposure. Haven't we all read how the rats that got cancer from saccharine had epic doses? It was just magnitudes more than a human would consume.

If an observational study won't cut it (I see you, @xthedeerlordx, and appreciate your comment and explanation), how does one prove the causation? Don't you need randomized controlled trials which would be extremely onerous controlling for various factors and basically making the (ideally large number of) participants live in a lab for whatever amount of time the study takes to really prove causation? I'd genuinely like to know. It seems like for a lot of things correlation after correlation after correlation is the best we're going to get.

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[–] Techpriest@lemmy.world 10 points 1 year ago

So basically what most European nations discovered 20 years ago?

[–] test_scientist@lemmy.world 9 points 1 year ago (2 children)

Possible carcinogen is an extremely low standard for the WHO, this probably means close to nothing

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[–] blazera@kbin.social 9 points 1 year ago

If anyone's seen aspartame's wikipedia article, it's like the most corporate compromised entry I've seen. In fact this very report is already being covered up there.

[–] Deestan@lemmy.world 8 points 1 year ago* (last edited 1 year ago)

WHO is one of those organizations whose advice I wish I could take at face value, but with anything that should be science based, it only takes a few disappointing compromises to take away a lot of trust.

Like the one time they wanted to recommend member states to consider Traditional Chinese Medicine for COVID-19 treatment

And how their recommendations result in our country's maternity wards try acupuncture and breathing as pain relief first, leaving mothers in debilitating pain for hours before giving them any of the real, safe, proven painkillers.

I get the reasoning - that accepting the commonly held medical belief of e.g. China allows them to hold some authority there and be a more global force of good - but to me it just make anything they say go on the "ok interesting, I'll fact check it later" pile.

[–] Thorny_Thicket@sopuli.xyz 8 points 1 year ago (6 children)

Aspartame just like about anything is not good for you in large quantities. This probably doesn't concern you if you just drink moderate amounts of sugar free drinks.

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[–] Zpiritual@lemmy.world 7 points 1 year ago (1 children)

Worth point out is that it doesn't even reach the same classification as red meat which is classified as probably causing cancer.

[–] sock@lemmy.world 3 points 1 year ago

theres a lot of things that MIGHT cause cancer i feel like if youre drinking enough diet coke to cause cancer its not the sweetener its your impulse control

[–] zorrothefox2001@lemmy.world 6 points 1 year ago* (last edited 1 year ago) (3 children)

Full disclosure I'm going completely tangential for this one.

I find it believable at best that aspartame can cause cancer, but causing weight gain just makes no sense to me.

I used to be FAT. 250 lbs. I didn't really make that many changes to my diet, except for cutting refined sugars way back.

I switched to Diet Coke, got off the little debbies, and I slimmed right down and now I'm hovering around 135.

It would make sense to say that I would maintain that weight or maybe gained more if aspartame was as harmful as this article says, but I'm not seeing it.

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[–] ilex@lemmy.world 5 points 1 year ago* (last edited 1 year ago) (1 children)

Does aspartame cause cancer?

In general, the American Cancer Society does not determine if something causes cancer (that is, if it is a carcinogen), but we do look to other respected organizations for help with this. Based on current research, some of these organizations have made the following determinations:

The US Food and Drug Administration (FDA) has concluded that “the use of aspartame as a general purpose sweetener… is safe.”

The European Food Safety Authority (EFSA) has stated, “Studies do not suggest an increased risk associated with aspartame consumption for… leukaemia, brain tumours or a variety of cancers, including brain, lymphatic and haematopoietic (blood) cancers.”

Though research into a possible link between aspartame and cancer continues, these agencies agree that studies done so far have not found such a link.

[–] coz@lemmy.world 2 points 1 year ago* (last edited 1 year ago) (1 children)

There was a study that found that Aspartame increased cancer risk, which was used as the base for all the current claims. The study was found to be flawed and it has not been reproduced since then, but due to confirmation bias and the desire to manipulate others the idea keeps communicating. That's one weakness of science, you can make up research and the average person will use it to confirm their biases, even if it's one study versus a hundred

That being said, there may be other risks with artificial sweeteners, I'm just talking about that specific study

Science is complicated and most people don't know how to apply it. For example, an university graduate does not know how to read published research and how to apply it to the real world, because beyond training that needs a lot of practice and feedback. People think that hearing the news or reading the paper will let them know the truth; it won't because they haven't developed the capacity to do so, yet they ask for a source they can't really understand. That's why you are supposed to go to a professional instead of doing what you think you should do on your own

The only people I've found that are worth giving sources to are PhDs or experts in their fields. Everyone else just fucks up interpreting them

[–] ilex@lemmy.world 2 points 1 year ago* (last edited 1 year ago)

Oh shit. I replied to the wrong comment. I only meant to post that other comment to yours. My b.

[–] VitoCorleone@lemmy.world 4 points 1 year ago (6 children)

Don't freak out (yet) people...

They put aspartame in the "possibly carcinogenic" category which is their least certain one. Also in this category we have... Radio waves (sigh)... Yeah right...

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[–] aragon@lemmy.world 4 points 1 year ago (2 children)

There are so many artificial sweetners in the market now.Even purely natural onea like stevia powders have maltitol added to it. It might be better to give up sweet things completely may be with the exception of fruits for better health.

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[–] JackbyDev@programming.dev 4 points 1 year ago (3 children)

Is this going to be like pork where it's a ~20% increase in cancer or like smoking where it's like a super huge increase?

[–] T0rrent01@lemmy.world 2 points 1 year ago

I remember the pork thing, and also reading that infographic about how it's hypocritical to refrain from eating dogs and cats because those animals are smart, but to eat pigs and octopuses anyway despite their similar levels of intelligence. Things like these are what eventually set me on the path of embracing veganism.

Garbage in, garbage out.

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[–] ipkpjersi@lemmy.one 3 points 1 year ago

This is basically the case for every artificial sweetener lol

[–] gzrrt@kbin.social 3 points 1 year ago

Regular and diet sodas are both clearly junk that humans shouldn't be consuming.

[–] dimlo@lemmy.world 3 points 1 year ago

So it’s like the list of carcinogens in California that everything is basically carcinogenic

[–] visiblink@lemmy.sdf.org 2 points 1 year ago

It was controversial from day one. When it was approved in Canada in 1981, my parents wouldn't let us touch the stuff.

But it's shadier than I thought: Donald Rumsfeld (yeah, Iraq invasion Donald Rumsfeld) was the CEO of the company that produced it and immediately after being sworn in, Ronald Reagan cleared the way for approval.

[–] NecoArcKbinAccount@kbin.social 2 points 1 year ago (2 children)

wtf I literally had a diet coke for the first time in my life the other day, and this comes up? Am I gonna get cancer now???

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[–] Crow@lemmy.world 2 points 1 year ago (1 children)

Luckily I find the taste of aspartame very off-putting. Please don’t take my sucralose.

[–] Bazoogle@lemmy.world 3 points 1 year ago (1 children)

Interesting. I can hardly distinguish aspartame and sucralose. Both taste disgusting. Give me my diabetes inducing high fructose corn syrup please.

[–] root_beer@kbin.social 2 points 1 year ago

Word, they all have that awful aftertaste, even stevia and xylitol have it. I don’t get where people are coming from when they say splenda is amazing, maybe there’s a genetic component to how I perceive it.

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