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For Firefox users, there is media bias / propaganda / fact check plugin.
https://addons.mozilla.org/en-US/firefox/addon/media-bias-fact-check/
- Consider including the article’s mediabiasfactcheck.com/ link
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It's going to be difficult to fund a large enough RCT to find a stat signif effect - it would be very expensive to follow people for 20-40 years and keep them in a study (10 000 people?). Similar to supplement studies - they may be effective, however big pharma won't pay for RCTs for products that are already on the market and with little profit margin.
Unfortuantely, it's not all 100% science - politics has a large hand to play here.
As I wrote elsewhere, there was one review showing potential biochemical and physiological mechanisms. It doesn't prove anything, however due to the amount consumed, it is worth investigating further and keeping an open mind:
https://pubmed.ncbi.nlm.nih.gov/28938797/ https://academic.oup.com/nutritionreviews/article/75/9/718/4101228
CONCLUSION
Current scientific knowledge about the safety of aspartame, as reviewed here, is based mostly on animal studies. These studies suggest that aspartame, even at recommended safe dosages, might not be safe. Several of these studies (in vitro as well as in vivo) that investigated both higher and safe dosages indicate that aspartame or its metabolites cause an oxidant/antioxidant imbalance, induce oxidative stress, and damage membrane integrity (lipid, protein, and nucleic acid), possibly affecting most cells and tissues. Aspartame is directly involved in the development of oxidative stress, which is a hallmark of systemic inflammation (Figure 3). Several animal studies have also reported a deleterious effect of aspartame exposure on body weight, adiposity, and/or glucose tolerance and insulin levels. These are summarized in a 2016 review by Fowler.125 Thus, there is a need for additional detailed human studies and comprehensive characterizations of the physiological processes affected by aspartame. This is of particular importance, as diabetic and other individuals with gut dysbiosis may already be at increased risk of systemic inflammation because of the inflammatory nature of their conditions. Data reviewed in this paper suggest that aspartame use could not only exacerbate existing systemic inflammation but also cause inflammation if healthy individuals ingest it on a regular basis.